7/10/2023 0 Comments Liquid liquid extraction methodCellulac, Purac, and NatureWorks are researching ways to use lignocellulosic biomass as a carbohydrate source to produce lactic acid (Biddy et al. 2016). In fermentation, the substrates for LA production can be renewable and can utilize low cost raw materials such as starchy materials (Wang et al. 2010 Li et al. 2012 Nakano et al. 2012 Prückler et al. 2015), sugarcane (Laopaiboon et al.2010), whey (Tejayadi and Cheryan 1995 Kim et al. 2006 Li and Shahbazi 2006), glycerol (Kishida et al. 2005 Yin et al. 2016), and microalgae (Nguyen et al. 2012). Musashino Chemical Laboratory, Ltd., in Tokyo, Japan, is the sole producer of synthetic LA, producing on the order of approximately 7,000 metric tons per year (Biddy et al. 2016 Musashino Chemical Laboratory 2017).įermentation is preferred for the production of LA, and about 90% of LA is produced by fermentation (Joglekar et al. Chemical synthesis produces only a racemic mixture of LA using acetaldehyde as a starting material. There are two processes used in LA production: chemical synthesis and carbohydrate fermentation. Global LA and PLA demands are expected to reach 1,960.1 and 1,205.3 kilo tons, respectively, by 2020 (Grand View Research 2015). Demand for LA has grown dramatically in recent years due to its potential as a building block for the production of poly-lactic acid (PLA) materials (Abdel-Rahman and Sonomoto 2016) and use as feedstock to produce green solvents. LA is used globally for applications in food, pharmaceutical, textiles, cosmetics, and chemical industries. Keywords: Lactic acid Membranes Precipitation Separation processes Solvent extractionĬontact information: School of Chemical Engineering, University of Campinas, Box 6066, 13083-970, Campinas-SP, Brazil *Corresponding author: acid (LA) is an alpha-hydroxy acid with dual functional groups, making it suitable for use in a variety of chemical transformations and products (Biddy et al. 2016). Separation and Purification Technologies for Lactic Acid – A Brief ReviewĪndrea Komesu,* Maria Regina Wolf Maciel, and Rubens Maciel Filho Advances in such recovery processes and drawbacks that limit the application of these technologies at the industrial level are also presented. This review discusses different processes that are currently employed for lactic acid recovery, focusing on precipitation, solvent extraction, and separation with membranes. Thus, efficient downstream processes are very important because they account for 50% of the production costs. After fermentation, the broth needs to be purified to obtain pure lactic acid for further uses. Production of lactic acid by fermentation is advantageous because renewable and low cost raw materials can be used as substrates. Lactic acid is an important platform chemical with a wide range of applications. "Separation and purification technologies for lactic acid – A brief review," BioRes.
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